What TEMOSIDE 250MG is used for?
TEMOSIDE 250MG is used for the treatment of specific forms of brain tumours such as,
- Newly-diagnosed glioblastoma multiforme
- Anaplastic astrocytoma
TEMOSIDE 250MG is used in these tumours if they return or get worse after standard treatment.
Warning & Precautions
Talk to Doctor
Talk to your doctor before you take this medicine, if you:
- Are allergic to temozolomide or any of the other ingredients of this medicine
- Have had an allergic reaction to dacarbazine (an anticancer medicine sometimes called DTIC)
- Have severely reduced blood cells (myelosuppression), such as your white blood, red blood and platelet count
- Have serious form of chest infection called Pneumocystis jirovecii pneumonia (PCP)
- Have ever had or might now have a hepatitis B infection
- May have a small risk of other changes in blood cells, including leukaemia
- More prone to infections, bruising or bleeding
- Have liver or kidney problems
Pregnancy & Breast Feeding
- Effective contraceptive precautions must be taken by patients who are taking TEMOSIDE 250MG
- You should stop breast-feeding while receiving treatment with TEMOSIDE 250MG
- If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine
Children & Adolescents
- Do not give this medicine to children under the age of 3 years because it has not been established
Driving & Using Machines
- TEMOSIDE 250MG may make you feel tired or sleepy. In this case, do not drive or use any tools or machines or cycle until you see how this medicine affects you
Tell your doctor if you are taking,
- have recently taken or might take any other medicines including medicine obtained without prescription, vitamin supplements and herbal products
How to Use
- Take this medicine on an empty stomach; for example, at least one hour before you plan to eat breakfast. Swallow it whole with a glass of water
- Do not open, crush or chew the medicine
- Take your prescribed dose of TEMOSIDE 250MG once a day, preferably at the same time each day
- Avoid being near people who are sick or have infections. Consult your doctor if you develop symptoms of opportunistic infections (such as Pneumocystis jirovecii pneumonia) and reactivation of infections (such as hepatitis B virus) Using temozolomide may increase your risk of developing certain types of bone marrow cancer. Be aware about your specific risk.
- You may be given medication to prevent nausea or other side effects while you are receiving temozolomide.
- Your blood will be tested frequently during treatment to monitor the side effects of temozolomide on your blood cells as you may have a small risk of other changes in blood cells, including leukemia.
- Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
- Do not drink alcohol while taking temozolomide.
- Do not drive or operate machinery while using temozolomide as it may make you tired or sleepy.
- Both male and female patients should take effective contraceptive precautions during and after 6 months of treatment. Male patients should seek advice on conservation of sperm prior to treatment as temozolomide treatment may cause infertility.
If you take more TEMOSIDE 250MG
- If you accidentally take more TEMOSIDE 250MG than you were told to, contact your doctor immediately
If you forget to take TEMOSIDE 250MG
- Take the missed dose as soon as possible during the same day
- Do not take a double dose to make up for a forgotten dose, unless your doctor tells you to do so
If you stop taking TEMOSIDE 250MG
- Do not stop taking this medicine unless your doctor has told you to do so
Like all medicines, this medicine can cause side effects, although not everybody gets them
- A severe allergic (hypersensitive) reaction (hives, wheezing or other breathing difficulty)
- Uncontrolled bleeding
- Seizures (convulsions)
- Fever, chills
- Severe headache that does not go away
- A reduction in certain kinds of blood cells. This may cause you to have increased bruising or bleeding, anaemia (a shortage of red blood cells), fever, and reduced resistance to infections
- Infections, wound infection
- Increased sugar in the blood, loss of weight
- Change in mental status or alertness, anxiety/depression, sleepiness, difficulty speaking, impaired balance, dizziness, confusion, forgetfulness, difficulty concentrating
- Inability to fall asleep or stay asleep, tingling sensation, bruising, shaking, abnormal or blurry vision, double vision
- Hearing impairment
- Shortness of breath, cough
- Blood clot in the legs, fluid retention, swollen legs
- Stomach upset
- Difficulty swallowing, dry mouth
- Skin irritation or redness, dry skin, itching
- Muscle weakness, painful joints, muscle aches and pains
- Frequent urination, difficulty with holding your urine
- Allergic reaction, fever,
- Radiation injury, face swelling, pain
- Abnormal taste
- Reduced number of blood cells (neutropenia or lymphopenia, thrombocytopenia)
- Flu-like symptoms, red spots under the skin
- Low potassium level in the blood, weight gain
- Mood swings, hallucination and memory impairment, partial paralysis, impaired coordination, impaired sensations, partial loss of vision
- Dry or painful eyes, deafness, infection of the middle ear, ringing in the ears, earache, palpitations (when you can feel your heart beat)
- Blood clot in the lung, high blood pressure, pneumonia, inflammation of your sinuses, bronchitis, a cold or the flu
- Swollen stomach, difficulty controlling your bowel movements, haemorrhoids
- Peeling skin, increased skin sensitivity to sunlight, change in skin colour, increased sweating
- Muscle damage, back pain
- Vaginal bleeding, sexual impotence, absent or heavy menstrual periods, vaginal irritation, breast pain
- Hot flushes, shivering, discoloration of your tongue, change in your sense of smell, thirst, tooth disorder
- Cough, infections including pneumonia
- Skin redness, urticaria (hives), skin eruption, allergic reactions
HOW TO COPE WITH SIDE EFFECTS?
The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.
Coping with Nausea and Vomiting
You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop feeling sick. Speak to your doctor if your condition does not improve.
Coping with Headache
Make sure you rest and drink plenty of fluids. Rest in a quiet, dimly lit room. Do not sleep more than you normally would. Do not strain your eyes (for example by looking at a screen). Do not drink alcohol. Headaches are usually temporary and usually go away with time. Ask your doctor to recommend a painkiller if they last longer than a week or get worse.
Coping with Rash
There are many treatments for a wide range of skin problems. Avoid hot showers or baths because hot water can irritate the skin. Make sure to pat your skin dry after a bath or shower. Do not rub or scratch the affected area. Leave the skin exposed to the air as much as possible. Do not use perfumed soaps or deodorants. Water containing chlorine can make most skin problems worse so avoid swimming. Avoid spicy foods, alcohol, tobacco smoke and caffeine as it may also make itching worse. Avoid excessive sun exposure, always use sunscreen and protective clothing when outdoors. Moisturizers can be used regularly to soothe and hydrate the affected area. If it does not get better within a week, speak to a pharmacist or doctor.
- Keep this medicine out of reach of children
- Store at room temperature (15-25°C)
- Do not use this medicine after the expiry date
Temoside is an anti-cancer (antineoplastic or cytotoxic) chemotherapy drug. It is used to treat specific types of brain tumor. It is a radiosensitizer
Q. Is Temoside effective/ does Temoside work?
Temoside is effective and works for patients if taken at recommended dosage and duration as recommended by the doctor
Q. How is Temoside given/administered/ metabolized/ how long does Temoside stay in the body?
Temoside is given as a capsule and is taken by mouth. It should be administered in the fasting state, at least one hour before meal. It is rapidly metabolized at physiologic pH to the active monomethyl triazenoimidazole carboxamide (MTIC). The half-life (t1/2) in plasma is approximately 1.8 hours
Q. How does Temoside cross the blood-brain barrier?
Temoside because of its small size and lipophilic properties is able to cross the blood-brain barrier rapidly and is present in the cerebrospinal fluid
Q. Does Temoside cause hair loss?
Hair loss is a side effect of using Temoside. Always follow doctor's advice regarding its use
Q. Is Temoside FDA approved?
Temoside is a FDA approved drug.
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